Vagal Nerve Stimulation in Refractory Epilepsy

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Vagal nerve stimulation for refractory epilepsy: a brief review

Vagus nerve stimulation (VNS) is an effective adjunctive treatment for patients with drugresistance epilepsy. Short and long-term VNS studies demonstrate a seizure-suppressing effect, with a more efficacy in long-term treatment. Precise mechanisms of VNS in attenuating seizure are not fully understood. Clarification of VNS mechanisms of action may improve its clinical efficacy, as it may provid...

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Respiratory pattern changes in sleep in children on vagal nerve stimulation for refractory epilepsy.

BACKGROUND An altered breathing pattern in sleep, over two to three weeks, reported by the parents of a child on Vagal Nerve Stimulation (VNS) therapy for refractory epilepsy, prompted a sleep study in him. His polysomnography (PSG) revealed respiratory irregularity concordant with VNS activation. Dyspnoea is a well recognised and reported side effect of the VNS. However there are only a few st...

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Vagus nerve stimulation for refractory epilepsy

Vagus nerve stimulation (VNS) is a neurophysiological treatment for patients with medically or surgically refractory epilepsy. Since the first human implant in 1989, more than 10 000 patients have been treated with VNS. Two randomized controlled studies have shown a statistically significant decrease in seizure frequency during a 12-week treatment period versus a baseline period when 'high stim...

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Vagus Nerve Stimulation for Refractory Epilepsy

Context: Vagus nerve stimulation (VNS) is a relatively new treatment for epilepsy. Past studies have proposed that the antiepileptic action is related to the effect on the brainstem reticular activating system, and is mediated largely by the widespread release of two inhibitory agents (gamma aminobutyric acid [GABA] and glycine). Objective: To confirm the safety and efficacy of vagus nerve stim...

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Vagal nerve stimulation for the treatment of medically refractory epilepsy: a review of the current literature.

OBJECT The authors conducted a study to evaluate the published results of vagal nerve stimulation (VNS) for medically refractory seizures according to evidence-based criteria. METHODS The authors performed a review of available literature published between 1980 and 2010. Inclusion criteria for articles included more than 10 patients evaluated, average follow-up of 1 or more years, inclusion o...

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ژورنال

عنوان ژورنال: Archives of Pediatrics & Adolescent Medicine

سال: 2003

ISSN: 1072-4710

DOI: 10.1001/archpedi.157.6.560